Pivotal Role for Endothelial Tetrahydrobiopterin in Pulmonary Hypertension
نویسندگان
چکیده
منابع مشابه
Pivotal role for endothelial tetrahydrobiopterin in pulmonary hypertension.
BACKGROUND Pulmonary hypertension is a fatal disease characterized by vasoconstriction and vascular remodeling. Loss of endothelial nitric oxide bioavailability is implicated in pulmonary hypertension pathogenesis. Recent evidence suggests that the cofactor tetrahydrobiopterin (BH4) is an important regulator of nitric oxide synthase enzymatic function. METHODS AND RESULTS In the hph-1 mouse w...
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The regulation of pulmonary vascular tone is a complex process and represents a balance between constrictor and dilator influences. In pulmonary hypertension, whether caused by hypoxia or flowand pressure-induced remodeling, the balance is tilted predominantly toward vasoconstriction. Despite decades of research, the initiating events in most patients with primary pulmonary hypertension remain ...
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ژورنال
عنوان ژورنال: Circulation
سال: 2005
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.0000162470.26840.89